Direct Coombs test

What is the Direct Coombs Test?

The Direct Coombs Test, also known as the direct antiglobulin test (DAT), is a diagnostic procedure used to detect antibodies or complement proteins attached to the surface of red blood cells. This test is essential in diagnosing various conditions that can lead to hemolytic anemia.

Why is the Direct Coombs Test Important?

This test is crucial for identifying autoimmune hemolytic anemia, where the body’s immune system mistakenly attacks its own red blood cells. It helps healthcare providers determine the underlying cause of hemolysis and guide appropriate treatment options.

How is the Direct Coombs Test Performed?

A blood sample is drawn from the patient and mixed with Coombs reagent. If agglutination (clumping) occurs, it indicates the presence of antibodies or complement proteins on the red blood cells. This positive result confirms the diagnosis of conditions like hemolytic disease of the newborn or transfusion reactions.